Base de dados : HANSEN
Pesquisa : CONTAGEM DE CELULAS SANGUINEAS [Descritor de assunto]
Referências encontradas : 5 [refinar]
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  1 / 5 HANSEN  
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Id:18988
Autor:Maslov, A. K; Luzhnova, S. A; Kalyanina, O. V
Título:Effects of horseradish root on functional activity of phagocytes, total blood cell count, and state of the liver in mice with experimental leprosy
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Fonte:s.l; s.n; 2002. 3 p. tab.
Resumo:Therapy of experimental leprosy with dried and grated horseradish root administered perorally in a dose of 300 mg/kg mixed food and treatment with purified horseradish peroxidase increased myeloperoxidase activity of blood neutrophils, enhanced antimicrobial functions of phagocytes, decreased leukocytosis, normalized total blood cell count, and produced no adverse effects on the functional state of the liver in mice. (AU).
Descritores:CONTAGEM DE CELULAS SANGUINEAS
RELACAO DOSE-RESPOSTA A DROGA
HANSENIASE/imunol
HANSENIASE/fisiopatol
FAGOCITOS/ef drogas
FAGOCITOS/imunol
CAMUNDONGOS ENDOGÂMICOS CBA
FIGADO/ef drogas
FIGADO/imunol
FIGADO/fisiopatol
RAIZES DE PLANTA/quim
ARMORACIA/quim
Limites:ANIMAL
CAMUNDONGOS
Meio Eletrônico: - .
Localização:BR191.1; 09146/s


  2 / 5 HANSEN  
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Id:18935
Autor:Halim, N. K. D; Ogbeide, E
Título:Haematological alterations in leprosy patients treated with dapsone
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Fonte:s.l; s.n; Feb. 2002. 3 p. tab.
Resumo:OBJECTIVE: To evaluate the haemoglobin concentration (Hb); total white blood cell count (WBC), differential WBC count; platelet count and reticulocyte count in leprosy patients already treated with dapsone. DESIGN: A case-control study. SETTING: Specialist Hospital Ossiomo, which is a Leprosarium and Haematology laboratory, University of Benin Teaching Hospital (UBTH), Nigeria. SUBJECTS: Seventy six leprosy patients (forty males and thirty six females) age range 13-40 years on single dose dapsone. RESULTS: The haemoglobin concentration showed a marked decrease while the reticulocyte count was markedly elevated which was suggestive of haemolytic anaemia. There was also lymphocytosis in patients during pre and post dapsone therapy. CONCLUSION: Leprosy patients on a dosage of 100 mg dapsone, are prone to haemolytic anaemia. Leprosy patients should routinely have their Hb, WBC, platelet count and reticulocyte count determined, while on dapsone therapy in order to ascertain the presence of haemolysis. (AU).
Descritores:ANTIMALARICOS/uso terap
CONTAGEM DE CELULAS SANGUINEAS
ESTUDOS DE CASOS E CONTROLES
DAPSONA/uso terap
HEMOGLOBINAS/anal
HANSENIASE/sangue
HANSENIASE/quimioter
CONTAGEM DE RETICULOCITOS
Limites:HUMANO
MASCULINO
FEMININO
ADULTO
SUPPORT, NON-U.S. GOV'T
ADOLESCENTE
Meio Eletrônico: - .
Localização:BR191.1; 09103/s


  3 / 5 HANSEN  
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Id:18476
Autor:Queiroz, Regina Helena Costa; Souza, Ana Maria de; Sampaio, Suely Vilela; Melchior Junior, Enzo
Título:Biochemical and hematological side effects of clofazimine in leprosy patients
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Fonte:s.l; s.n; 2002. 4 p. tab.
Resumo:Gastrointestinal toxicity and red skin discoloration were the major side effects observed in leprosy patients undergoing long-term treatment with clofazimine (CFZ). Hematological and biochemical alterations have been cited among other side effects; however, their real magnitude and clinical significance at the doses currently employed in therapy have not been sufficiently documented. We therefore investigated the correlation between CFZ plasma concentration and biochemical (transaminases, bilirubins, alkaline phosphatase, gamma-glutamyltransferase, amylase, urea, creatinine, and potassium plasma levels) as well as hematological changes blood and reticulocyte counts, osmotic fragility, detection of Heinz bodies and methemoglobinemia (MHM), following in two regimes of treatment: CFZ as a single drug and CFZ as part of multidrug (MDT) therapy, in combination with dapsone and rifampicin. MHM and hemolytic anemia were detected in the MDT group only. Eosinophilia was found in patients of either group. Determination of hepatic, pancreatic and renal biochemical parameters showed rare, occasional changes of apparently no clinical significance. We conclude that CFZ is a generally well tolerated and safe drug when given as a daily dose of 50mg, which is currently used in leprosy patients. (AU).
Descritores:CONTAGEM DE CELULAS SANGUINEAS
CLOFAZIMINA/admin
CLOFAZIMINA/ef adv
CLOFAZIMINA/uso terap
DAPSONA/admin
DAPSONA/ef adv
DAPSONA/uso terap
QUIMIOTERAPIA COMBINADA
HANSENOSTATICOS/admin
HANSENOSTATICOS/ef adv
HANSENOSTATICOS/uso terap
HANSENIASE/sangue
HANSENIASE/quimioter
RIFAMPINA/admin
RIFAMPINA/ef adv
RIFAMPINA/uso terap
Limites:SUPPORT, NON-U.S. GOV'T
FEMININO
HUMANO
MASCULINO
Meio Eletrônico: - .
Localização:BR191.1; 08998/s


  4 / 5 HANSEN  
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Id:17918
Autor:Levine, Peter H; Weintraub, Lewis R
Título:Pseudoleukemia during recovery from dapsone-induced agranulocytosis
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Fonte:s.l; s.n; may 1968. 6 p. ilus, graf.
Resumo:The case presented here illustrates how convincingly the recovery from agranulocytosis may mimic acute leukemia in both the peripheral blood and the bone marrow. The development of a leukemia-like syndrome in any patient who has been exposed to a drug known to cause agranulocytosis should raise the question of pseudoleukemia. Repeated bone marrow aspirations and daily observation of changes in peripheral blood parameters will help prevent needless exposure to myelossuppressive agents. The experience with this case makes mandatory an awareness of agranulocytosis as a side effect of dapsone.(AU).
Descritores:AGRANULOCITOSE/ind quim
AGRANULOCITOSE/diag
CONTAGEM DE CELULAS SANGUINEAS
CELULAS DA MEDULA OSSEA
DAPSONA
DIAGNOSTICO DIFERENCIAL
CONTAGEM DE LEUCOCITOS
DERMATOPATIAS/quimioter
Meio Eletrônico: - .
Localização:BR191.1; 01860/s


  5 / 5 HANSEN  
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Id:14993
Autor:Maslov, A. K; Luzhnova, S. A
Título:Effects of peroxidase therapy on functional state of the liver and phagocytes and blood cell counts in mice with experimental leprosy
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Fonte:s.l; s.n; 2000. 5 p. ilus, tab, graf.
Descritores:HANSENIASE
HANSENIASE
FIGADO
FIGADO
CONTAGEM DE CÉLULAS SANGUINEAS
PEROXIDASE DO RABANO SILVESTRE
MICROSCOPIA ELETRONICA
PEROXIDASE
FAGOCITOS
FAGOCITOS
CAMUNDONGOS ENDOGAMICOS CBA
Limites:ANIMAL
CAMUNDONGOS
Localização:BR191.1; 07330/s



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